AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury
نویسندگان
چکیده
Heart failure is one of the leading causes death and disability worldwide. Left ventricle remodeling, fibrosis, ischemia/reperfusion injury all contribute to deterioration cardiac function predispose onset heart failure. Adenosine monophosphate-activated protein kinase (AMPK) universally recognized energy sensor which responds low ATP levels restores cellular metabolism. AMPK activation controls numerous processes and, in heart, it plays a pivotal role preventing progression disease. Excessive reactive oxygen species (ROS) generation, known as oxidative stress, can activate AMPK, conferring an additional redox-sensor. In this review, we discuss recent insights into crosstalk between ROS AMPK. We describe molecular mechanisms by how signaling further prevent progression. Ultimately, review potential therapeutic approaches target for treatment cardiovascular disease prevention • generation redox sensor. reduces stress acting on Nox, mitochondria antioxidant enzyme expression. crucial controlling ischemia-reperfusion, hypertrophy or atherosclerosis. By limiting ROS, protects from both HFpEF HFrEF.
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2021
ISSN: ['1873-4596', '0891-5849']
DOI: https://doi.org/10.1016/j.freeradbiomed.2021.02.047